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Creators/Authors contains: "Wang, Hongzhang"

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  1. ; ; ; ; ; ; ; (, ChemPhysChem)
    Abstract Many drugs adjust and/or control the spatiotemporal dynamics of periodic processes such as heartbeat, neuronal signaling and metabolism, often by interacting with proteins or oligopeptides. Here we use a quasi‐biocompatible, non‐equilibrium pH oscillatory system as a biomimetic biological clock to study the effect of pH‐responsive peptides on rhythm dynamics. The added peptides generate feedback that can lengthen or shorten the oscillatory period during which the peptides alternate between random coil and coiled‐coil conformations. This modulation of a chemical clock supports the notion that short peptide reagents may have utility as drugs to regulate human body clocks. 
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